Biosynthesis of Sulfated Glycans and Their Change in Colon Cancer

Akira Seko

doi:10.4052/tigg.1919.2SE

Trends in Glycoscience and Glycotechnology

Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352

Article for JSCR 40th Anniversary Issue

Biosynthesis of Sulfated Glycans and Their Change in Colon Cancer

Akira Seko

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Keywords: sulfotransferase, colon cancer, galactosyltransferase, N-acetylglucosaminyltransferase, keratan sulfate

JOURNAL FREE ACCESS

2019 Volume 31 Issue 181 Pages SE42-SE43

DOI https://doi.org/10.4052/tigg.1919.2SE

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Abstract

We studied enzymatic activities and biochemical properties of sulfo/glycotransferases responsible for the biosynthesis of sulfated glycans in normal colonic mucosa and colonic adenocarcinomas. We found the presence of a GlcNAc6ST which can catalyze 6-O-sulfation on GlcNAc residues of core 3 structure, in colonic mucinous adenocarcinomas. The presence of β1,4-galactosyltransferase (β4GalT) and β1,3-N-acetylglucosaminyltransferase (β3GnT) specific for GlcNAc 6-O-sulfate and Galβ1-4GlcNAc(6S), respectively, was also shown. These results will serve as studying physiological functions of sulfated glycans.

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