Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
Article for JSCR 40th Anniversary Issue
Biosynthesis of Sulfated Glycans and Their Change in Colon Cancer
Akira Seko
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2019 Volume 31 Issue 181 Pages SE42-SE43

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Abstract

We studied enzymatic activities and biochemical properties of sulfo/glycotransferases responsible for the biosynthesis of sulfated glycans in normal colonic mucosa and colonic adenocarcinomas. We found the presence of a GlcNAc6ST which can catalyze 6-O-sulfation on GlcNAc residues of core 3 structure, in colonic mucinous adenocarcinomas. The presence of β1,4-galactosyltransferase (β4GalT) and β1,3-N-acetylglucosaminyltransferase (β3GnT) specific for GlcNAc 6-O-sulfate and Galβ1-4GlcNAc(6S), respectively, was also shown. These results will serve as studying physiological functions of sulfated glycans.

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© 2019 FCCA (Forum: Carbohydrates Coming of Age)
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