Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
Article for JSCR 40th Anniversary Issue
Glycoprotein Quality Control Contributed by Secondary Factors
Kiichiro Totani
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2019 Volume 31 Issue 181 Pages SE59-SE60

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Abstract

Glycoprotein quality control is regulated by high-mannose glycans on the glycoprotein as signals. We found that the quality control mechanism is complementarily regulated by secondary factors other than glycan recognition through our glycoprobe-based analysis. We revealed that most related glycan-recognizing proteins discriminate the aglycon state difference of the substrate glycoprotein to regulate activity. We also found that the upstream of the glycan processing is accelerated and the downstream is decelerated under the molecular crowding conditions mimicking the inside of the cell. Furthermore, the effect of diseases such as obesity, type 2 diabetes, and osteoporosis on the operation status of glycoprotein quality control was clarified.

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© 2019 FCCA (Forum: Carbohydrates Coming of Age)
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