Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
Article for JSCR 40th Anniversary Issue
In Vivo Glycan Pattern Recognition Towards Drug Delivery System and Therapeutic In Vivo Synthetic Chemistry
Katsunori Tanaka
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2019 Volume 31 Issue 181 Pages SE61-SE62

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Abstract

We achieved in functioning the “glycan pattern recognition” in vivo, by clusterizing various N-glycans through efficient synthetic transformation, i.e., RIKEN click reaction. Such “glycan pattern recognition” could control the interaction with the target cells, organs and cancers, as well as regulate the excretion pathways in mice. Furthermore, we performed for the first time the metal catalyzed reaction at the targeted organs in mice, by rapidly carrying the metal catalyst using the glycan-based drug delivery system. We thus developed the next-generation strategy from the glycochemical biology, termed as “Therapeutic In Vivo Synthetic Chemistry”, where the activities of drugs or other bioactive molecules could be elicited without off-targeting problems by directly synthesizing them at the targeted diseases.

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© 2019 FCCA (Forum: Carbohydrates Coming of Age)
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