Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
Article for JSCR 40th Anniversary Issue
New Developments on the Early Stage of the Biosynthesis of Asparagine-Linked Glycans
Yoichiro Harada
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2019 Volume 31 Issue 181 Pages SE95-SE97

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Abstract

Asparagine (N)-linked glycosylation occurs on most secretory and membrane proteins synthesized in the endoplasmic reticulum (ER), which functions to modulate protein folding, degradation and intracellular trafficking. However, the regulatory mechanisms underlying N-linked glycosylation remain largely elusive, hindering our integrative understanding of the physiological and pathological functions of this posttranslational modification. In this article, I will introduce recent advances on our understanding of regulation of N-linked glycosylation and a newly discovered inhibitor of N-linked glycosylation reaction.

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© 2019 FCCA (Forum: Carbohydrates Coming of Age)
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