Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
Article for JSCR 40th Anniversary Issue
Biological Functions of Xylose 2-O-Phosphorylation and Dephosphorylation in the Glycosaminoglycan-Linkage Region Tetrasaccharide
Tomomi Izumikawa
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2019 Volume 31 Issue 181 Pages SE102-SE103


Glycosaminoglycans (GAGs) are linear polysaccharide chains covalently attached to core proteins to form proteoglycans (PGs). GAG chain assembly begins with the synthesis of the common protein linkage region tetrasaccharide attached to the serine residues of specific core proteins. Previous structural analyses have shown that the GAG-protein linkage region tetrasaccharide of PGs is transiently modified by xylose 2-O-phosphorylation. We previously identified a Xyl kinase that phosphorylates C-2 of the xylose residue and phosphoxylose phosphatase. This review presents recent advances in the biological significance of phosphorylation and dephosphorylation of the Xyl residues in the linkage region tetrasaccharide of PGs.

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© 2019 FCCA (Forum: Carbohydrates Coming of Age)
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