Lipid Conjugates as Ligands for the C-type Lectin Receptor Mincle

Abstract

C-type lectin receptors (CLRs), a class of pattern recognition receptors, are expressed on immune cell surfaces and regulate innate immunity by recognizing microbial or endogenous substances. Mincle, a CLR, recognizes various lipid conjugated ligands, such as glycolipids. In this review, recently synthetically accessed natural Mincle ligand-lipid conjugates as well as their analogues are discussed.