UDP-glucose:Glycoprotein Glucosyltransferase–Selenof Complex: A Potential Glycoprotein-folding Machine

Abstract

UDP-glucose:glycoprotein glucosyltransferase (UGGT) functions as a sensor for monitoring the folding status of glycoproteins and transferring a glucose residue to the oligomannose-type glycans of misfolded glycoproteins. Recently, we showed that UGGT1 facilitates folding of denatured glycoproteins in vitro. In this review, we discuss whether UGGT–selenof complex acts as a chaperone for misfolded glycoproteins based on the recently revealed conformation and function of UGGT and the function of selenof, which is a UGGT-binding protein.