Adrenal Cortical and Medullary Responsiveness to Insulin-induced Hypoglycemia
キーワード:
insulin hypoglycemia,
adrenal medullary secretion,
adrenal 17-hydroxycorticosteroid secretion
1971 年 105 巻 1 号 p. 27-33
詳細
1971 年 105 巻 1 号 p. 27-33
Experiments were done in dogs anesthetized with sodium pentobarbital. Adrenal venous blood was collected and analyzed for 17-hydroxycorticosteroids (17-OHCS), adrenaline and noradrenaline. The animals were injected intravenously with 1.0, 0.5, 0.1 and 0.05U/kg of insulin. After injection of 0.1-1.0U/kg of insulin the adrenal 17-OHCS and medullary secretion increased significantly. Following administration of 0.05U/kg of insulin, however, no significant increases were observed. Thus, there was no definite difference in responsiveness to insulin-induced hypoglycemia between the adrenal cortex and medulla.
