The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
A Metanephrine Test for a Screening of Catecholamine-producing Tumors
TATSUO SATO, KAORU YOSHINAGA
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Keywords: metanephrine, normetanephrine, pheochromocytoma, neuroblastoma
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1973 Volume 110 Issue 3 Pages 283-287

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Abstract

A simple method is described for the determination of free total metanephrine (metanephrine plus normetanephrine) in urine. The method includes direct oxidation of 3-methoxyamine metabolites of catecholamine to vanillin in alkaline urine and extraction of formed vanillin with toluene which is followed by spectrophotometrical assay. The method has been proved its reliability and simplicity for screening of patients with catecholamine-producing tumors.

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