The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Effect of Immunization with an Allogeneic Tumor on the Growth of Primary Methylcholanthrene-Induced Sarcomas in Rats
ISAMU USUBUCHIHAJIME KUDOMASAFUMI KANOMICHIO SUGA
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1976 Volume 119 Issue 1 Pages 79-83

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Abstract

Making use of common antigenicity among allogeneic tumors, the immunotherapy against primary 3-methylcholanthrene(MCA). induced sarcomas in rats was attempted. At the time when MCA-induced sarcomas reached approximately 1cm in diameter, allogeneic Usubuchi sarcoma cells were injected 5 times into the subcutaneous tissue of rats. In most cases, inhibitory effect on the growth of the tumor was observed in the early period, but none of 29 cases treated resulted in final regress-ion. Twenty-nine non-treated cases showed uniformly progressive growth from the beginning. This result seems to indicate the possibility of using allogeneic tumor(s) for the immunotherapy against human cancer.

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