The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Platelet Aggregation and Plasma Levels of Beta-Thromboglobulin in Diabetes Mellitus
KENICHI YAMADAKAZUO MORIYOSHIO GOTO
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1981 Volume 135 Issue 4 Pages 423-429

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Abstract

YAMADA, K., MORI, K. and GOTO, Y. Platelet Aggregation and Plasma Levelsof Beta-Thromboglobulin in Diabetes Mellitus. Tohoku J. exp. Med., 1981, 135 (4), 423-429-In view of the tendency toward vascular complications in diabetesmellitus, we studied platelet aggregation and plasma beta-thromboglobulin (β-TG) levels in 35 healthy controls, 25 non-diabetic patients with ischemic heartdisease (IHD) and 85 diabetic patients. Blood platelets from diabetic patientsshowed no significant hyperaggregation induced by ADP, collagen or epinephrine, as compared with controls and non-diabetic patients with IHD, nor could bedemonstrated significant differences in platelet aggregation between diabetics withdiabetic microangiopathies and those without diabetic vascular complications.Significantly high levels of plasma β-TG were observed in diabetics in comparisonwith those in controls and non-diabetic patients with IHD. Patients withdiabetic microangiopathy had more significantly elevated β-TG levels thandiabetics without diabetic microangiopathies. Diabetics without diabeticmicroangiopathy had similar levels of β-TG to those of controls and non-diabeticpatients with IHD. High levels of plasma β-TG in diabetics with diabetic microangiopathyseem to indicate a platelet hyperfunction in vivo due to diabeticvascular complications, -platelet aggregation; diabetic microangiopathy; beta-thromboglobulin; diabetes mellitus; ischemic heart disease

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