Effects of Prostaglandins on Thrombus Formation in Mesenteric Arterioles of Rats

Abstract

SUZUKI, T., the late HAYASHI, A. and TAKANO, S. Effects of Prostaglandins on Thrombus Formation in Mesenteric Arterioles of Rats. Tohoku J. exp. Med., 1982, 137 (1), 65-71-Effects of locally applied prostaglandins on platelet thrombus formation in the mesenteric arterioles of rats were studied in vivo. Prostaglandin (PG) I₂ and PGE₁, which were reported to be powerful inhibitors of blood platelet aggregation, prevented the thrombus formation, whereas PGE₂, which was reported, in low concentrations, to enhance platelet aggregation, showed a tendency to promote the thrombus formation. PGA₁, PGA₂ or PGF_2α had no effect. PGD₂ had a very weak inhibitory effect. As prostaglandins tested had no effect on the diameter of mesenteric arterioles, it is assumed that the effectiveness of PGI₂ and PGE₁ in preventing thrombus formation is due mainly to their powerful inhibiting effects on platelet aggregation.