1989 年 158 巻 4 号 p. 283-289
OMATA, K., MATSUI, K., SATO, D., KAMIOKI, S., OUTI, H. and ABE, K. Atrial Natriuretic Polypeptide (ANP) as Protective Agent of Renal Ischemia. Tohoku J. Exp. Med., 1989, 158 (4), 283-289-The effect of atrial natriuretic polypeptide (ANP) on hemodynamics and renal function was evaluated after the reconstructive surgery of the left renal artery in a patient with renovasular hypertension secondary to Takayasu's arteritis. The reconstructive surgery was done using the femoral artery, since we were unable to obtain adequate vein segments to fit the renal artery. The femoral artery was reconstructed by her saphenous vein segments. After 30min of the aortorenal bypass operation, α-human ANP (α-hANP) was infused intravenously for 10min at a rate of 0.1μg/kg/min. Although total peripheral resistance was decreased by α-hANP infusion, blood pressure was not changed because of the increased cardiac output. Glomerular filtration rate was increased markedly with concomitant increases in urine volume and urinary excretions of sodium, potassium and phosphate. Fractional excretions of water and sodium were not changed, but fractional excretion of phosphate and potassium clearance were increased. Thus, the infusion of α-hANP markedly improved the renal function of the ischemic kidney by the reconstructive surgery of the renal artery, suggesting that α-hANP seems clinically applicable as a protective agent in renal ischemia at renovascular surgery as well as the renal transplantation.
