HAKOMORI, S. Functional Role of Glycosphingolipids in Tumor Progression. Tohoku J. Exp. Med., 1992, 168 (2), 211-222 -Molecular modeling of glycosphingolipids (GSLs), and their organization in membranes, suggest that GSL “patches” provide binding sites for interaction with ligands and adjacent cells, and that GSLs or their catabolites modulate transmembrane signaling. Aberrant GSL expression is a ubiquitous phenotype common to essentially all types of tumors, and leads to (i) formation of tumor-associated antigens defind by a large variety of monoclonal anti-bodies; (ii) aberrant adhesion favoring metastasis and invasiveness of tumor cells; and (iii) aberrant catabolism leading to altered transmembrane signaling and loss of growth control. Classical immunotherapy is based on (i). New approaches termed “antiadhesion” and “anti-signaling” therapy, based on (ii) and (iii), are hereby proposed. -antiadhesion therapy; glycosphingolipids; integrin family; anti-signaling therapy; tumor-associated antigen
- Effects of the Early Administration of Heparin in Patients With ST-Elevation Myocardial Infarction Treated by Primary Angioplasty
- Changes of Plasma Renin Activity Following Intracerebroventricular Administration of Biologically Active Peptides in Two-Kidney, One Clip Hypertensive Rats
- Hemoglobin Denaturation Caused by Surfactants
- Prediction of Molecular Interaction between Platelet Glycoprotein Ibα and von Willebrand Factor using Molecular Dynamics Simulations
- Platelets: Small in Size But Essential in the Regulation of Vascular Homeostasis – Translation From Basic Science to Clinical Medicine –
- About this Journal
The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology. - Submitted manuscripts will be screened for
plagiarism with Similarity Check (https://www.crossref.org/services/similarity-check/).
- Subscriptions
Inland subscriptions should be sent to Tohoku University Medical Press, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JAPAN.
Subscriptions from abroad should be addressed to MARUZEN CO., LTD., EXPORT DEPARTMENT, Postal address: P.O.Box 75, Shinagawa, Tokyo 140-8799, JAPAN.
e-mail: export@maruzen.co.jp