Influence of the Piqûre of Cl. Bernard upon the Epinephrine Discharge, the Blood Sugar Content and the Blood Pressure
1931 年 17 巻 3-4 号 p. 345-377
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1931 年 17 巻 3-4 号 p. 345-377
Bernard's puncture of the floor of the fourth ventricle was tried in the dogs, non-anaesthetized, non-fastened and non-laparotomized. The epinephrine output rate, the blood sugar, the mean arterial blood pressure, and the heart and respiration rate were simultaneously estimated as usual in this laboratory.
(1) Piqûre occasioned an abrupt elevation in the blood sugar content, roughly speaking from 0.1-0.12% to 0.15-0.2%; the peak was reached a few minutes to thirty minutes after piqûre (After piqûre blood samples were taken as a rule 5, 15, 30, 60 minutes, so on.), and the hyperglycaemic period lasted about a half hour to two hours.
(2) The epinephrine secretion rate was also accelerated; from the normal, quiet value of 0.00001-0.00002 mgrm. per kilo and per minute from one side gland it was augmented and reached the acme as 0.0001-0.0005 mgrm. per kilo and per minute, which was noted a few minutes or rather frequently thirty minutes after piqûre, and the hyperepinephrinaemic phase extended about two to three hours. And the total quantity of epinephrine secretcd by piqûre was estimated as 0.013-0.12 mgrm., mean 0.05 mgrm. from both glands. Further, an average of the amount of epinephrine secreted was 0.013 mgrm. per kilo in the first thirty minutes, 0.012 mgrm. per kilo in the next thirty minutes, 0.015 mgrm. per kilo in the second hour and 0.012 mgrm. per kilo in the third; in total 0.05 mgrm. from both glands.
The peak of the hyperglycaemia was found sometimes simultaneously with that of hyperepinephrinaemia, in others being preceded by the latter, and in still others the reverse. The mentioned order cannot be neglected in delving into the causal relationship between both matters.
(3) The mean blood pressure was also abruptly changed by piqûre, but its direction was not always the same, that is either a rise or a drop was induced, and at all events the change was only of short duration. The pulse rate reduced largely and the respiratory rate usually accelerated. The body temperature frequently rose though only a little.
(4) Ether anaesthesia rendered largely obscure these effects of piqûre upon the blood sugar content, the epinephrine secretion and the blood pressure. A new rise of the blood sugar level above the hyperglycaemia due to etherization and other sensory stimulation other than piqûre was missed frequently, and when detectable the excess was small; the hyperepinephrinaemia was however invariably detectable, but incomparably small and the height of its peak was also distinctly small compared with the nonanaesthetized experiments. The slowing influence of piqûre upon the heart rate appeared only far weakly under ether.
