The Intensity of the Augmented Epinephrine Liberation Elicitable by Asphyxiating the Non=Anaesthetized Dog

抄録

Non-anaesthetized dogs were asphyxiated by wrapping the nose and mouth with a wet towel with a rubber plate between its folds. 1.5-9 minutes were needed to cause stoppage of the respiration and unconsciousness, according to the tightness of the wrapping. The suprarenal vein blood was collected from time, the epinephrine was determined by means of the rabbitintestine segment. Blood sugar was simultaneously measured.
When asphyxia was carried out to the stopping of the breathing the output rate of epinephrine increased invariably, and its degree of augmentation apparently depended upon the depth of asphyxia, the sample collected in the first minute or the second following the termination of the asphyxiation showed the peak of the augmentation (No sample was collected during the carrying out of the asphyxiation.). The augmentatory period lasted from only a few minutes to about a half hour according to the degree of asphyxia. As the greatest acceleration was noted that of twenty times the initial, and 0.0016 mgrm. per kilo per minute. The double sectioning the splanchnic nerves wholly abolished this action of asphyxia.
The hyperglycaemia simultaneously occuring corresponded in degree to that of asphyxia, and also to that of the augmented liberation of epinephrine and its duration and the time interval with which its peak was reached were definitely longer than those of the hyperepinephrinaemia. It lasted for a half to one hour, or longer, and the peak of the hyperglycaemia was a few minutes behind that of the hyperepinephrinaemia as a rule. Double sectioning the great and small splanchnic nerves, which was done not long before starting the preparation for collecting the suprarenal vein blood, more or less largely reduced the asphyxia hyperglycaemia, but never totally.