Epinephrine Discharge, Blood Sugar and Blood Pressure in Anaphylactic Shock of Dogs, Non=Anaesthetized, Non=Fastened

Abstract

The epinephrine secretion rate was measured in dogs, non-anaesthetized, non-fastened, non-laparotomized, during the anaphylactic shock. Epinephrine was assayed by means of the rabbit intestine segment.
As in the peptone experiments of Watanabe, the epinephrine secretion rate was copiously accelerated. In moderate shock, a rate as 0.0006 mgrm. epinephrine per kilo per minute, about twenty to thirty times the preliminary normal rate, was noted a few minutes to a quarter of hour, and when a very severe shock occasioned, a rate 0.0015 mgrm. epinephrine per kilo per minute, about one hundred times the normal value, was observed. About two hours were needed until the preliminary velocity of epinephrine liberation regained.
The blood pressure fall and acceleration of the epinephrine output rate as well, precede definitely the outset of the hyperglycaemia by from one or two to some ten minutes. In a dog which died early by a very heavy shock, the hyperglycaemia could not be determined before the death, while the epinephrine output rate was very remarkably increased.§^*)