Studies on the Detoxicating Hormone of the Liver (Yakriton)

89th Report. Effect of Yakriton upon Phenylhydrazin Anemia in Animals of Low-classed Liver Power

Abstract

The present work was undertaken to test whether or not yakri-ton, -the detoxicating hormone of the liver, which does not contain the liver principle effectual in human pernicious anemia, -was effectu-al for experimental phenylhydrazin anemia in rabbits. Only b-classed animals were used in the present experiment.
The result was that the control group which received a daily sub-cutaneously injection of 1% phenylhydrazin in the amount of 1.5 c. c. per kilo grins. succumbed on the third injection in 3 cases (Cf. Tables 3a, 4a, and 6a) and onthe fourth injection in the other 3 cases (Cf. Tables la, 2a, and 5a), while in the yakriton group which received besides phe-nylhydrazin daily injections of yakriton in the amount of 1/10 R. A. U. per kilo of body weight, 2 rabbits died on the third injection (Cf. Tables 4b, and 6b), another was able to outlive 8 days after the third injec-tion (Cf. Table 3b). 2 other animals died on the fourth injection (Cf. Tables 2b, and 2c), and the other two were able to outlive the fourth in-jection and the ensu-ing severe anemia (Cf. Tables 1b and 5b).
It. has been shown that yakriton, the detoxicating hor-mone of the liver, is effectual in the phenylhydrazin poi-soning or severe ane-mia caused by it.