Blood Sugar Fluctuation Due to Double Administration of Glucose into the Duodenum

Abstract

The repeated glucose ingestion test, orally given, has been evaluated by the duodenal test. 30g. glucose was given to healthy persons and diabetics.
By the oral administration, the hyperglycemia due to the second dose is definitely smaller compared with the first, when tested on the healthy, and the second dose is answered in the diabetics with a greater hyper-glycemia than the first, as commonly well known.
The duodenal administration nearly annulled the smaller reaction against the second administration in healthy subjects, known as the Staub effect, and exaggerates the hyperglycemia in the diabetics more strongly than on the oral application.
Be the glycemic effect of repeated glucose ingestion in the normal person and the diabetic properly judged, it makes clear that each kind of application yield almost quite the same outcome in both healthy person and diabetic in relation to the sugar tolerance.
The smallness and retardation of the hyperglycemia due to the oral application, which take place in contrast to the duodenal, appear with a same magnitude in persons with tolerance, normal and lessened as well.