On Carcinoma of the Gallbladder with Special Reference to the Relation with Calculous or Inflammatory Diseases
1959 Volume 71 Issue 2 Pages 171-182
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1959 Volume 71 Issue 2 Pages 171-182
1. Twenty four cases with carcinoma of the gallbladder were studied histologically. In ten gallbladders, one to three early microscopic lesions of carcinoma were observed beside the main tumors, suggesting that the multicentric occurrence of the lesion is not unusual.
2. Among the above 24 cases, 15 (62.5 per cent) were complicated with calculi. Such a high rate of the concurrence suggested some relations between the two conditions, therefore thorough microscopic studies were performed on 237 gallbladders which had been ectomized for various surgical disorders other than neoplasms.
3. The papillary or adenomatous proliferations of the epithelium were observed in 31 (13.1 per cent) of the 237 cases, i.e. in 25 (14.6 per cent) of the 168 calculous and in six (8.7 per cent) of the 69 non-calculous cases, among which eight cases were evidently precancerous.
These epithelial overgrowths were, however, morc closely dependent upon the existence of the inflammations than the presence of calculi, and these were observed most commonly in cases with the marked chronic inflammations.
