Experimental Studies on Homologous Heart Transplantation
First Report: Part I. Techniques of the Transplantation Part II. The Behavior of the Transplanted Heart
1960 Volume 72 Issue 1 Pages 10-23
Details
1960 Volume 72 Issue 1 Pages 10-23
In order to find an approved technique and to study the general results of homologous canine heart transplantation, twenty-nine experiments were performed in three groups of dogs. After evaluations of the experiments with ECG, and pathological examination, the following results were obtained:
1. Twenty-nine transplantations were attempted and all were technically successful but one failed by coronary air-embolism.
2. Twelve transplants failed within 10 hours and most of the first group (5 of 6 cases) failed by left atrial rupture.
3. The third group, subjected to end-to-side anastomosis between the aorta and the carotid artery, showed most satisfactory results.
4. The longest period of survival of the transplant was 130 hours. ECG or pathological study was made with the transplant, and incompatibility of the transplant was discussed by pathological findings.
