Abstract
The present study was made of the effect of the X-ray irradiation and the intravenous injections of the radiopathogenic substance (Radiotoxin A) on the con-tent and the base composition of the nucleic acid in the liver, spleen, adrenal glands and bone marrow of rabbits.
The conclusions are as follows: (1) In rabitts with symptoms of radiation disturbance RNA in the liver and adrenal glands and DNA in the spleen and bone marrow showed a marked decrease. (2) Similar findings were obtained in the groups of injection of the radiopathogenic substance, Radiotoxin A. Especially in the group of serial injections of Radiotoxin A changes of RNA or DNA in the organs were more remarkable than in the groups irradiated with X-ray. (3) The base composition of the nucleic acid was changed by the X-ray irradiation or the intravenous injection of Radiotoxin A. That is, adenine of RNA in the liver decreased markedly and adenine of DNA in the spleen and bone marrow decreased too. Cytosine and uracil of RNA in the liver and cytosine and thymine of DNA in the spleen decreased, whereas cytosine of DNA in the bone marrow increased. Especially in the group of serial injections of Radiotoxin A there were the most remarkable changes.
