The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Concentration and Binding Capacity of Thyroxin-binding Prealbumin in Pregnancy, Hyper- and Hypothyroidism
Toshiro SakuradaShintaro SaitoKiyoshi InagakiSumio TayamaTatsuo Torikai
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1968 年 96 巻 3 号 p. 259-266

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Thyroxin-binding capacity and concentration of TBPA (thyroxin-binding pre-albumin) were investigated with polyacrylamide gel electrophoresis in hyper- and hypothyroid patients before and after therapy, and in pregnant women before and after parturition. Binding capacity of TBG (thyroxin-binding globulin), free thy-roxin in plasma and other parameters of thyroid functions were also measured in these conditions.
Endogenous thyroxin decreased both the binding capacity and concentration of TBPA as did endogenous estrogen. In contrast, endogenous thyroxin decreased and endogenous estrogen increased the binding capacity of TBG.
Positive correlation was found between the binding capacity and concentra-tion of TBPA. Consequently, it was assumed that endogenous thyroxin decreased and estrogen increased the concentration of TBG.
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© Tohoku University Medical Press
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