The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Hyperalaninemia with Pyruvicemia due to Pyruvate Carboxylase Deficiency of the Liver
Toshio YoshidaKeiya TadaTasuke KonnoTsuneo Arakawa
Author information
JOURNALS FREE ACCESS

1969 Volume 99 Issue 2 Pages 121-128

Details
Abstract

A 10-year-old girl with mental retardation, hyperalaninemia and pyruvicemia was described. Studies on liver biopsy specimens from this patient revealed that pyruvate carboxylase activity was markedly decreased, whereas both pyruvate decarboxylation and glutamic pyruvic transaminase were normal in activity. Furthermore, it was found that an incorporation of pyruvate-2-14C into glycogen in the liver was markedly diminished in the patient as compared with that in a control.
These findings suggest that the metabolic lesion in the patient with hyper-alaninemia and pyruvicemia is a defective activity of pyruvate carboxylase of the liver, leading to an impaired gluconeogenesis.

Information related to the author
© Tohoku University Medical Press
Previous article Next article
feedback
Top