Dielectric Study of Liposome Dispersion Using Statistical Analysis of Jitter

抄録

We observed molecular dynamics of Dipalmitoyl Phosphatidylcholine liposome water dispersion by dielectric spectroscopy measurement. Statistical analysis of jitter used in the present paper is a new technique developed to observe dielectric behaviors more precisely in higher frequency range from 1 GHz to 30 GHz for time domain reflectometry method. Though the relaxation time obtained shows common temperature dependence, the relaxation time distribution parameter β decreased around the gel-liquid crystalline phase transition temperature with increasing temperature from 36 ℃ to 48 ℃. It is suggested that surrounding water of lipid membrane may form the particular water structure in the LC phase different from bulky water in the gel phase with a change in the mobility for hydrophobic regions of the lipid bilayer.