Separation capability of proteins using microfluidic system with dendrimer modified surface

抄録

Microscale and nanoscale chip are adaptable to the future of microreactors and small sensors. Interactions between proteins and biomaterials surfaces correlate with many important phenomena in biological systems. In this research, we investigated the separation capability of proteins using microfluidic system, involving modified surface with poly(amidoamine) (PAMAM) dendrimer and poly(2-methacryloyloxylethyl phosphorylcholine(MPC)-co-n-butyl methacrylate(BMA)) (PMB30W). The PAMAM dendrimer and PMB30W provided a facile way to inhibit non-specific protein adsorption, and influenced flow velocities of proteins. We believe the microfluidic device with dendrimer coated surface plays important role in the development of useful materials for biomolecular separation.