Preparation and Characterization of Soluble Wool Keratin for Human Hair Care

抄録

Soluble wool keratin was prepared by derivatization of disulfide (SS) bonds of cysteine residue to carboxymethylalanyl disulfide (CMAD) groups. The solubilization reaction was carried out in 0.2 M thioglycolic acid aqueous solution under alkaline conditions (pH 13.0 and 13.5). The solubilization reaction was performed by derivatization reaction including reduction and oxidation reaction. Carboxymethylalanyl disulfide keratin (CMADK) with desirable molar mass can be obtained by changing reaction conditions. Part of CMADK molecules showed helical structure. To investigate the prevention of hair damage by bleaching and permanent waving treatments, CMADK with low molar mass was prepared at pH 13.5 and 60°C for 3h. It was added to permanent waving agent and the bleaching and permanent waving treatments were carried out. The treated hair was hardly damaged even if the treatment was repeated for 3 times. CMADK is effective for prevention of hair damage.