Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
Diagnosis, Treatment
Divergence Factor in HbA1c Measurement with Domestic and/or International Standard Material-Divergence Factor between POCT HbA1c Measurement DCA2000/DCA Vantage and the Domestic Daily Method Used in Japan-
Shuji OguchiTerumichi NakagawaMidori IshibashiMitsuru Murata
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2012 Volume 55 Issue 6 Pages 386-391

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Abstract

We investigated the divergence factor between HbA1c measurement using DCA2000/Vantage (DCA) and the domestic daily method used in Japan referencing the KO 500 method, i.e., JSCC/JDS standard measurement. Calibration settings of the international standardization material and of DCA internal calibration material mostly resembled DCA measurement but measured 7 % to 10 % lower in relative percentage than the KO 500 method setting. KO500 chromatography recognized the peak of foreign substances not recognized by JDS Lot 4 in calibration of the international standardization material or of the DCA internal calibration material. The DCA divergence factor was thought to be caused by a difference in standard material composition or a difference in operation method separation capability. DCA showed a valid result by adopting calibration decided by the Japan Diabetes Society (JDS) and supplied the product based on JDS Lot 4 from July 2010.

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© 2012 Japan Diabetes Society
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