糖尿病
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
赤血球ブドウ糖6リン酸脱水素酵素に関する研究 (II) 赤血球Stroma中の本酵素活性化因子と糖尿病
各務 守正
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ジャーナル フリー

1968 年 11 巻 4 号 p. 228-232

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In the previous study of author, the relation between erythrocyte G6PD activity and insulin was examined. Consideration of various possibilities suggested that the relation between the G6PD activity of the erythrocytes of a diabetic patient and the “activating factor” of this enzyme in the stroma would be an interesting subject of study. In the present study, effects of the stroma obtained from a erythrocytes of a healthy individual and effects of that from a diabetic patient on the hemolysates G6PD of untreated diabetic patient, and the relation between the effects and insulin were examined.
Following results were obtained:
1) In the case when hemolysate of an untreated diabetic patient was incubated together with stroma from an untreated diabetic patient, no effects were observed in G6PD activity, but when the former was incubated together with stroma from a healthy individual, significant rise in G6PD activity was noticed.
2) In the case when hemolysate of a healthy individual was incubated with stroma obtained from another healthy individual and/or from an untreated diabetic patient, G6PD activity did not change.
3) No rise in G6PD activity in the hemolysate of an untreated diabetic patient was noticed when insulin was added to stroma from untreated diabetic patient.
Judging from above results, it may be supposed that in the stroma of a healthy individual there exists an “activating factor”( “stroma factor”) of G6PD activity and that G6PD in his hemolysate is of active type. On the other hand, it may be supposed that in a diabetic patient there is some defficiency of the “stroma factor” and that a considerable amount of G6PD as an inactive type is contained in his hemolysate.

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