Liver and retinae of rats fed with high fat diet for 100-400 days were compared with those of rats fed with normal diet. The following results were obtained.
1) Gluconeogenesis was increased, glycolysis was impaired in liver slices of high fat diet group in concomitant with disturbed carbohydrate tolerance, while normal diet group had no changes.
2) The incorporation of glucose-U-C14 into CO, in retinae of high fat fed rats were significantly lowerd than those of normally fed rats.
3) In retinae of high fat fed rats for 400 days, dilatations of blood vessels, degenerations of the ganglion cells and retinal bleedings were observed.
4) In tryptic digestes of retinae of high fat fed rats, microaneurysm was not demonstrated, but decreases in pericytes were observed. However, in retinae of the controll rats, no significant retinal changes were observed.
5) These changes observed in high fat fed rats were discussed in relation to the increased oxidation of fatty acid and pathogenesis of diabetic retinopathy.
