1969 年 12 巻 6 号 p. 465-473
Glucose tolerance test in mass-examination for a community or multiphasic screening in hospitals have offered much knowledge about the blood glucose level of aged people, but enough data do not seem to have been made on children or young adults. In this paper, screening tests for diabetes mellitus for primary school children and junior and senior high school students were described, and also a follow-up study was presented on those students revealing their abnormal blood glucose level, “borderline case” by definition.
Two methods for screening test were employed; One, a total of 2, 039 subjects aged 6 through 17 years old, were tested for urine glucose. Eighty subjects who indicated positive urine sugar were further invited to glucose tolerance test, and 11 cases were found “abnormal” in their blood glucose level, exceeding either 160 mg/100 ml for one-hour level or 120mg/100ml for two-hour level, or both.
The other, a total of 453 high school students, aged 15 years old, were examined for blood glucose onehour after glucose admioistration, in addition to routine urine test for glucose. Glucose tolerance test was performed on 14 subjects who had blood glucose level exceeding 160 mg/100 ml and/or positive urine sugar and 5 cases moved to be “abnormal” according to the above criteria. On the other hand, out of the remaining 439 subjects excluding 14 positive screenees, a random sample of 97 cases was taken, and subjected to glucose tolerance test as well, resulting in finding 13 “abnormal” cases by the same criteria. It is concluded (1) that those with elevated blood glucose level are not necessarily few in young subjects, not only in urineglucose-positives but also in negatives, and (2) that these rates are not so lower than those in an aged population.
Furthermore, a follow-up was conducted on seven cases showed abnormal blood glucose level for a 1-through 4-year period. It was observed that 5 cases took a favourable course with a decrease of blood glucose level to a normal range, 2 cases remained unchanged and no case got worse, Thus it is indicated that, in young subjects as well as in the aged, blood glucose level would considerably fluctuate. Therefore, the upper limits of “normal” blood glucose level are actually higher than those generally accepted, advocating the authors' hypothesis that those indicated slightly elevated blood glucose level belong to “normal” population and would not develop diabetes mellitus in good agreement with the authors' opinion discussed elsewhere.