1970 年 13 巻 3 号 p. 264-272
The serum insulin response of diabetic subjects is reported to be higher than that of nondiabetic ones, and there are also studies which reported lower insulin response in diabetics.
In order to clarify this discrepancy or changes from high insulin response to low one, the relationship between glucose tolerance curve and serum insulin response was investigated.
Two hundred and fourteen males and one hundred and thirty-two females, untreated diabetic or obese, were studied. As controls eleven males and fourteen females, healthy and non-obese, were used.
One hundred glucose was administered orally, and serum sample were obtained at fasting, half, one, one and half, two and three hours after administrati on.
Serum blood sugar, FFA and IRI were determined.
The results are as follows:
1) The IRI response of borderline hyperglycemic subjects was higher and more delayed than that of normal ones. The patterns of responses of blood sugar and IRI are quite similiar each other.
2) The IRI response of diabetic subjects with fasting blood sugar level of less than 119 mg/dl was highest among tested, and the peak rise of insulin was retarded till two hours after glucose loading.
3) The IRI response became lower little by little, coincidently with the progress of decrease of glucose tolerance. Especially, diabetics with fasting blood sugar level of more than 160 mg/dl showed very low insulin response in comparison with those of less blood sugar value.
4) In subjects with same glucose tolerance, obese group showed higher insulin response than non-obese one. Both had lower insulin response with the progress of decrease of glucose tolerance.
5) The ratio ΔIRI/Δ Blood Sugar during initial thirty minutes after glucose loading decreased with the lowering of glucose tolerance.
6) Fasting levels of FFA in serums of diabetic, borderline and normal subjects were high in this order, but there was no significant difference in their falling rate after glucose loading.