1972 年 15 巻 5 号 p. 329-335
Relationship between glucose tolerance and degree of obesity was studied in 924 subjects (694 male, 234 female) who received a medical close examination. Evaluation of 50 g of oral glucose torelance test was carried out according to the criteria suggested by the Japan Diabetic Society. The following findings were obtained.
1) Subjects who showed a normal, borderline and diabetic types of glucose tolerance curvewere 31.2, 57.1 and 11.8 % of the total subjects, respectively. There was little difference in the distribution between both sexes.
2) In both sexes, number of subjects showing a diabetic curves increase, whereas that of those showing a normal curve decrease with advance of age.
3) Among the individuals who were between 40 and 59 year old, those who were classifiedas diabetic type had a significantly greater degree of obesity than those who belong to the other two types. This findings suggests that obesity may play a primary role in etiology of diabetes mellitus only among the people with these ages.
4) On the contrary, in groups of individuals who were either under 40 or above 60 year old, there was no significant difference in degree of obesity among the three types. This observations indicates that factors other than obesity may contribute more greatly to the genesis of diabetes mellitus among the persons with these ages.
5) Individuals with family histories of diabetes had a higher frequency in the diabetic type and lower frequency in the normal type. However, there was no correlation between these frequencies and degree of obesity.
6) Likewise, in subjects with hypertension, the frequency of the diabetic type was higher and that of the normal type lower than the average values. Furthermore, hypertensive persons who were classified as the diabetic or the borderline types showed a significantly greater degree of obesity than that of the normal type.