NSYマウス (自然発症糖尿病マウス) の腎ソルビトールについて

抄録

N. S. Y. mouse is a new strain of congenital diabetic mice derived from the I.C.R. strain which possesses abnormal findings on small vessels of the glomerulus and is considered to be a useful model for human diabetes. According to the osmotic theory, intracellular accumulation of sorbitol has been implicated in the initiation of the cataract and the neuropathy resulting from diabetes.
The present study was conducted to estimate the role of sorbitol on the development of renal disease in the N. S. Y. mice. In result, the concentrations of glucose and sorbitol were simillar in the kidney of N. S. Y. mice and age-matched nondiabetic controls. This result suggests that the activity of aldose reductase is low in the kidney of N. S. Y. mice and sorbitol does not play a main role in the appearance of renal disease in the N. S. Y. mice.