糖尿病
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
家族性Lecithin: Cholesterol Acyltransferase欠損症における赤血球のインスリン受容体
赤沼 安夫門脇 孝鈴来 和男岡 芳知春日 雅人岩本 安彦佐久間 真樹
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1983 年 26 巻 7 号 p. 769-772

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Insulin binding was studied using erythrocytes obtained from two homozygotes of familial partial deficiency of plasma lecithin: cholesterol acyltransferase (LCAT). Both patients revealed corneal opacity, plasma LCAT activity with 14-15% of the normal value, target cells and abnormalities of plasma lipoprotein composition with a reduced ester ratio of cholesterol. In addition, abnormalities of lipid composition of red cell ghosts were observed: cells obtained from both patient showed increased amounts of cholesterol and lecithin and an increase in the lecithin/sphingomyelin ratio.
Insulin binding to the red cells was also increased, mainly due to an increase in binding affinity without a significant change in receptor number. Further studies are needed to confirm whether the increase in binding affinity is due to the change in lipid composition of the red cell membrane.

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© 社団法人 日本糖尿病学会
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