抄録
One of the troublesome complication in diabetic patients is peripheral neuropathy, particularly numbness and tingling. We have assessed the effects of new drugs for the treatment of peripheral neuropathy. The patients with peripheral neuropathy had subjective symptoms, such as numbness, tingling, severe pain and a sensation of tightness. Twenty-three patients with diabetic neuropathy were given trimetazidine which has vasodilator and vasomotion. An action aldose-reductase inhibitor (ONO-2235) was given to another 19 patients with neuropathy. Sixteen individuals with diabetic neuropathy were treated with prostaglandin E1 by the drip infusion method, and lipoprostaglandin E1 which is a lipid emulsion of prostaglandin E1 particles was administrated to 10 diabetic patients with neuropathy. For evaluating the clinical effects of these agents, sbjective symptoms, vibration sensation, peripheral nerve conduction velocity and R-R interval on the electrocardiogrm were observed before and after administration. For each agent there was a tendency foward improvement of was and significant improvement in vibration sensation subjective symptoms observed.
