糖尿病
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
抗腫瘍剤Hydroxyurea (HU) の投与によりヘモグロビンA1の著明なfalse elevationをきたした糖尿病の1症例
戸谷 理英子植田 太郎高橋 良当雨宮 禎子平田 幸正
著者情報
キーワード: HU, HbF, HbA1, 慢性骨髄性白血病
ジャーナル フリー

1990 年 33 巻 3 号 p. 237-239

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False elevations of glycosylated hemoglobin levels are well known in situations such as chronic renal failure. hemoglobinopathy and in the administration of certain drugs. We report a case of a 67-year-old reasonably well-controlled diabetic patient who showed marked dissociation of HbA, and HbA, c levels after introduction of the anti-neoplastic agent hydroxyurea (HU) for treatment of concomitant chronic myelogenous leukemia (CML). Analysis of glycosylated hemoglobin revealed that the false elevation of HbA, level was largely due to the increased synthesis of HbF induced by HU.
In addition in vitro incubation of the patient's washed erythrocytes in the presence of heated HU for 5 days caused substantial elevations of both HbA, a d-b and HbA, c levels, suggesting the possible formation of carbamylated counterparts.
As HU is frequently used in the treatment of myeloproliferative disorders, it should be noted that this drug is capable of inducing false elevation of HbA, levels.

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