糖尿病における心拍変動を表す3指標の測定値の比較

抄録

Although the measurement of beatto-beat heart rate variation is generally accepted as a valid test, there is still considerable debate as to which currently available method is the most practical for general clinical use. This study was designed to assess which test is most suitable in terms of the relationship with diabetic neuropathy.
Three different methods of analysing RR interval (heart rate) variation were compared in 16 normal subjects and 48 diabetics with responses to diabetic neurological measurements such as achilles tendon reflex, blood pressure fall on standing, and motor conduction velocity of the tibial nerve. The subjects selected were all in their 40s so as to exclude the influence of age as much as possible.
Hinge spread of RR intervals on deep breathing differentiated most accurately not only between normal subjects and diabetics, but also between diabetics with and without neurological damage. The coefficient of variation of RR intervals at rest and the difference between the maximum and minimum heart rates on deep breathing did not differentiate groups more accurately than the hinge spread of RR intervals.
Therefore, for routine clinical usage, we conclude that recording the hinge spread of RR interval variation on deep breathing is the most practical method currently available.