糖尿病
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
糖尿病患者の赤血球膜からのハイドロキシ飽和脂肪酸の検出
井上 正幸傳 秋光鳴瀧 恭也
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ジャーナル フリー

1994 年 37 巻 4 号 p. 311-315

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Extracted lipids from erythrocyte membranes were analyzed by gas chromatographic mass spectrometry.Hydroxy stearic acid and hydroxy lignoceric acid were not detected in healthy subjects but were present in diabetic patients, using ion chromatography.Findings were confirmed by mass spectrometry.These analytical findings suggest that 1) peroxidation of poly-unsaturated fatty acids occurs due to the suppression of superoxide dismutase activity in diabetic erythrocytes, 2) from a physiochemical point of view, these hydroxy fatty acids might be associated with reduced fluidity of the erythrocyte membranes in diabetics, and 3) ion chromatography is useful for detecting hydroxy fatty acids of erythrocyte membranes.

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© 社団法人 日本糖尿病学会
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