抄録
The effect of lipid metabolism, especially catabolism of triglyceride on carbohydrate metabolism, has been studied in rabbits.
The results were as follows;
1) A high fat diet did not increase the fasting blood sugar but this level was significantly elevated by the addition of orally adminitered Δ' 17α-methyltestosterone.
2) The oral administration of lipid or Δ' 17α-methyltesterone increased the urinary excretion of the ketone bodies. The urinary excretion of ketone bodies was higher than when either alone was given. The serum ketone bodies increased after the treatment with Δ' 17α-methyltestosterone but was not affected by high-fat diet.
3) Administration of propionic acid resulted in an elevation of the fasting blood glucose and impaired the glucose tolerance. These effects were found more evident in the former than the latter. Lactic acid did not have these effects. Addition of beef tallow made these effects more prominent.
4) Oral administration of 17 a-methyltestosterone or short-chain fatty acids (propionate, butyrate and lactate) caused a reduction in liver glycogen.
5) Adminirtration of beef tallow increased the lipid deposition of hepatic cells. This finding was also found in the group where Δ' 17α-methyltestosterone was added to the standard diet.
6) Fasting for 5 days caused an elevation of blood sugar and an impairment of glucose tolerance. An injection of purified human depot fat made these changes more remarkable.
7) On the basis of these observations, a discussion was made whether the acceleration of lipid metabolism might play an important role in diabetogenesis or not.
