1996 Volume 9 Issue 4 Pages 305-313
Protective effect of Sobuzoxane (MST-16) against cardiotoxicity of adriamycin (ADM) was inves-tigated in rabbits. ADM (1.0mg/kg) was administered intravenously twice a week for five weeks. MST-16(25mg/kg, p.o.) or ICRF- 187 (25mg/kg, i.p.) was administered 60 or 30 minutes, respectively, before the injection of ADM. The hearts were examined histologically and biochemically at four weeks after accomplishment of administration. In the ADM-administered rabbits, severe vacuolation and loss of myofibrils were observed in the myocardium of the left ventricle by light microscopic observation. In addition, invasion of macrophages and proliferation of fibroblasts were seen in the connective tissue of the myocardium. Electron microscopic observa-tion revealed characteristic alterations of the cardiac myocytes in the ADM treated groups, namely dilation of the sarcoplasmic reticulum and myelin figures derived from mitochondria. These ADM-induced lesions were ameliorated when MST-16 or ICRF-187 was pretreated. However, levels of lipid peroxide and antioxidant enzyme activities of the cardiac muscles were not significantly different from the control values in either experimental group. It is suggested that MST-16 could be a candidate drug for preventing ADM-induced cardiomyopathy.
