ラットによる多層カーボンナノチューブ（MWCNT）の長期気管内反復投与試験：1年経過時点における報告

前野 愛; 北條 幹; 坂本 義光; 湯澤 勝廣; 長谷川 悠子; 久保 喜一; 長澤 明道; 安藤 弘; 田中 和良; 海鉾 藤文; 生嶋 清美; 山本 行男; 鈴木 俊也; 猪又 明子; 守安 貴子; 高橋 祐次; 横田 理; 小林 憲弘; 広瀬 明彦; 中江 大

doi:10.14869/toxpt.47.1.0_P-130

The 47th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-130

DOI https://doi.org/10.14869/toxpt.47.1.0_P-130

Conference information

Host: The Japanese Society of Toxicology

Name : The 47th Annual Meeting of the Japanese Society of Toxicology

Date : 2020 -

Poster

Chronic toxicity study of multi-walled carbon nanotubes (MWCNT) in rats by repeated intratracheal instillations: a progress report at 1 year

*Ai MAENO, Motoki HOJO, Yoshimitsu SAKAMOTO, Katsuhiro YUZAWA, Yuko HASEGAWA, Yoshikazu KUBO, Akemichi NAGASAWA, Hiroshi ANDO, Kazuyoshi TANAKA, Fujifumi KAIHOKO, Kiyomi IKUSHIMA, Yukio YAMAMOTO, Toshinari SUZUKI, Akiko INOMATA, Takako MORIYASU, Yuhji TAQUAHASHI, Satoshi YOKOTA, Norihiro KOBAYASHI, Akihiko HIROSE, Dai NAKAE

Author information

*Ai MAENO
Tokyo Metropolitan Institute of Public Health
Motoki HOJO
Tokyo Metropolitan Institute of Public Health
Yoshimitsu SAKAMOTO
Tokyo Metropolitan Institute of Public Health
Katsuhiro YUZAWA
Tokyo Metropolitan Institute of Public Health
Yuko HASEGAWA
Tokyo Metropolitan Institute of Public Health
Yoshikazu KUBO
Tokyo Metropolitan Institute of Public Health
Akemichi NAGASAWA
Tokyo Metropolitan Institute of Public Health
Hiroshi ANDO
Tokyo Metropolitan Institute of Public Health
Kazuyoshi TANAKA
Tokyo Metropolitan Institute of Public Health
Fujifumi KAIHOKO
Tokyo Metropolitan Institute of Public Health
Kiyomi IKUSHIMA
Tokyo Metropolitan Institute of Public Health
Yukio YAMAMOTO
Tokyo Metropolitan Institute of Public Health
Toshinari SUZUKI
Tokyo Metropolitan Institute of Public Health
Akiko INOMATA
Tokyo Metropolitan Institute of Public Health
Takako MORIYASU
Tokyo Metropolitan Institute of Public Health
Yuhji TAQUAHASHI
National Institute of Health Sciences
Satoshi YOKOTA
National Institute of Health Sciences
Norihiro KOBAYASHI
National Institute of Health Sciences
Akihiko HIROSE
National Institute of Health Sciences
Dai NAKAE
Tokyo University of Agriculture

CONFERENCE PROCEEDINGS FREE ACCESS

Details

Abstract

To look for a potential alternative to a two-year inhalation study of MWCNT, we now perform a chronic toxicity study designed to intermittently expose MWNT-7 to F344 male rats by the intratracheally instillation method with dose of 0, 0.125 or 0.5 mg/kg BW at every 4 weeks. Aggregation of MWCNT-laden macrophages associated with hyperplasias of type II alveolar cell was prominent in lungs of satellite animals at 0.5- and 1- yr after the beginning of the study. Cell numbers in BALF increased dose- and time- dependently. No lung tumors and pleural mesotheliomas were observed until now.

Corresponding author

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