Host: The Japanese Society of Toxicology
Name : The 47th Annual Meeting of the Japanese Society of Toxicology
Date : 2020 -
In this presentation, I introduce detecting potential of developmental neurotoxicity by analysis of hippocampal neurogenesis, and then, induction of aberrant neurogenesis by developmental exposure to neurotoxicants targeting mature neurons. Next, I present availability of hippocampal neurogenesis for detecting developmental neurotoxicity in a framework of 28-day toxicity study. Finally, I show examples of biomarkers for detection of developmental neurotoxicity obtained by global gene screening techniques, in particular, irreversible markers downregulated by hypermethylation.