Annual Meeting of the Japanese Society of Toxicology
The 47th Annual Meeting of the Japanese Society of Toxicology
Session ID : S5-1
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Symposium 5
Evaluation of in vivo neurotoxicity by analysis on aberrations in hippocampal neurogenesis
*Makoto SHIBUTANI
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CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

In this presentation, I introduce detecting potential of developmental neurotoxicity by analysis of hippocampal neurogenesis, and then, induction of aberrant neurogenesis by developmental exposure to neurotoxicants targeting mature neurons. Next, I present availability of hippocampal neurogenesis for detecting developmental neurotoxicity in a framework of 28-day toxicity study. Finally, I show examples of biomarkers for detection of developmental neurotoxicity obtained by global gene screening techniques, in particular, irreversible markers downregulated by hypermethylation.

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© 2020 The Japanese Society of Toxicology
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