Studies on molecular mechanisms of mutation induction and suppression using genetically modified cells

Abstract

DNA damages induce mutations, resulting in biological effects such as cancers. Organisms equip various defense systems against DNA damages. To understand the mechanisms of mutagenesis, we need to know the relationships between the defense systems and mutagenesis by the damages. Genetic modification is useful approach to know the roles of defense systems against mutagenesis by DNA damages.

In this symposium, I will introduce application of genetically modified cells in molecular mechanism studies for mutation control with a focus on the results using DNA polymerase ζ gene-modified cells.