2026 年 12 巻 p. 3-5
Recent advances in dementia research have substantially improved our understanding of its pathogenesis, prevention, and treatment. While disease-modifying therapies, such as anti-amyloid-β monoclonal antibodies, have ushered in a new era in Alzheimer’s disease management, increasing attention has been directed toward dementia prevention strategies. Accumulating evidence suggests that lifestyle-related diseases, particularly vascular risk factors, play a critical role in cognitive decline and dementia development. This review discusses the relationship between vascular health and dementia prevention, with a focus on nutritional interventions and brain-targeted supplements, especially omega-3 polyunsaturated fatty acids, as adjunctive strategies for neuroprotection.
