Chronic toxicity of cyclocarbothiamine was investigated on the Wistar rats of both sexes. The sample was mixed into food at the concentration of 30,100 and 300mg%, and administered orally to the test animals for 3 and 6 months. No deleterious effect was observed on their behavior, growth curve, food intake, and organ weights, nor were there any abnormal finding on autopsy and hematology. Histopathological examination of the lungs, liver, kidneys, adrenals, thyroid, pancreas, spleen, bone marrow, gastro-intestinal tracts, brain, and other 5 organs showed no observable chronic toxicity effect of cyclocarbothiamine, given orally in larger dosis for 3 and 6 months continuously.
