抄録
Some of modified thiamine compounds stimulated the growth of Kloeckera apiculata more strongly than thiamine but the growth by these compounds was more effectively inhibited by oxythiamine than the growth by thiamine, inhibited by oxythiamine. 5O% inhibition index to oxythiamine ; thiamine, 68,000 ; thiamine propyldisulfide (TPD), 4,600 ; benzoylthiamine monophosphate (BTMP), 210 and S-carbethoxythiamine (CET), 42. The accumulation of these compounds on Kloeckera cells was inhibited by oxythiamine ; inversely proportional to inhibition index. Kloeckera cells, when preincubated and accumulated with TPD or BTMP, were inhibited by oxythiamine on the growth test to the same extent as thiamine, whereas cells preincubated with CET were inhibited more strongly by oxythiamine than those with TPD or BTMP. These differences could be explained by the stability of CET and easy reversion of TPD or BTMP to thiamine.
