Abstract
Blood sugar and serum immunoreactive insulin levels after loading of a large quantity of various B-vitamins were studied in normal subjects and diabetic patients. Fall in blood glucose was caused by pyridoxal phosphate and folic acid. This effect was exaggerated on depancreatized dogs only in the presence of insulin but not in the absence of insulin. A transient hypoglycemia was found by pyridoxal phosphate loading in eviscerated rats with continuous infusion of insulin, whereas it was not demonstrated by folic acid.
