1971 年 44 巻 1 号 p. 37-43
Changes of potassium and sodium contents in isolated guinea-pig atria kept in modified Locke's solution without KCl were prevented by thiamine tetrahydrofurfuryl disulfide (TTFD) added to the medium. This effect was seen, also, at absence of TTFD in the medium when atria were pretreated with TTFD. These effects were not seen when thiamine or DMPD (dimethalium propyl disulfide) was used in place of TTFD. Transportation of TTFD, thiamine or DMPD into atria was tested by means of those labeled compounds with ^<14>C. ^<14>C-Thiamine was identified in atria treated with ^<14>C-TTFD. Transportation of TTFD into atria was far markedly more than that of thiamine or DMPD.