抄録
Two derivatives of pyridoxine monooctanoate were synthesized. α^4-O-Octanoyl pyridoxine (PIN-4MO) and α^5-O-octanoyl pyridoxine (PIN-5MO) were hydrolyzed in 10% aqueous solution of acetone at pH 1〜3 following an apparent first-order reaction. At the pH range of 1〜7,PIN-4MO was hydrolyzed 10 times as fast as PIN-5MO. At pH 4〜12,an interconversion between the two derivatives was found. At the pH range higher than 9,their hydrolysis was enhanced with an increase of pH and the total amount recovered as PIN and PIN-MO was 60〜80% for each derivative. The residue fraction was found to be water-soluble and reactive with imide reagent. The structure of this fraction was left unknown in the present study. The treatment of PIN-MO in 50% aqueous ethanol or methanol solution for 48 hours at pH 7 and 60℃ resulted in 4-ethoxy PIN and 4-methoxy PIN dimer.
